substance with a high potential for abuse similar to other opioids including hydrocodone, hydromorphone, methadone, morphine, oxycodone, oxymorphone, and tapentadol. For clinically significant respiratory or circulatory depression secondary to fentanyl overdose, administer an opioid antagonist. Examples of accidental exposure include transfer of a Duragesic patch from an adult's body to a child while hugging, sharing the same bed as the patient, accidental sitting on a patch and possible accidental exposure of a caregiver's skin to the medication in the patch. Limit treatment to the minimum effective dosages and durations.
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When you first start taking Duragesic, when your dose is changed, or if you take too much (overdose serious or life threatening breathing problems that can lead to death may occur. Talk to your healthcare provider if you have questions about skin application sites. Store in original unopened pouch. Initiate the dosing regimen for each patient individually, taking into account the patient's severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse see Warnings and Precautions (5.1). Peel: Peel off both parts of the protective liner from the patch. Avoid sensitive areas or those that move around a lot. Clinical Considerations Monitor infants exposed to Duragesic through breast milk for excess sedation and respiratory depression. Hepatic Impairment A clinical pharmacology study with Duragesic in patients with cirrhosis has shown that systemic fentanyl exposure increased in these patients.
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